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Masahisa Katsuno Selected Research

polyglutamine

1/2022Nucleic Acid-Based Therapeutic Approach for Spinal and Bulbar Muscular Atrophy and Related Neurological Disorders.
1/2022The Combined Efficacy of a Two-Year Period of Cybernic Treatment With a Wearable Cyborg Hybrid-Assistive Limb and Leuprorelin Therapy in a Patient With Spinal and Bulbar Muscular Atrophy: A Case Report.
6/2021Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS.
1/2020Arginine is a disease modifier for polyQ disease models that stabilizes polyQ protein conformation.
8/2019Long-term Effects of Androgen Deprivation in a Patient with Spinal and Bulbar Muscular Atrophy - A Case Report with 14 Years of Follow-up.
1/2019Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy.
1/2019DNA methylation inhibitor attenuates polyglutamine-induced neurodegeneration by regulating Hes5.
1/2016BIIB021, a synthetic Hsp90 inhibitor, induces mutant ataxin-1 degradation through the activation of heat shock factor 1.
1/2016A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy.
1/2016MiR-298 Counteracts Mutant Androgen Receptor Toxicity in Spinal and Bulbar Muscular Atrophy.
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Masahisa Katsuno Research Topics

Disease

78X-Linked Bulbo-Spinal Atrophy
07/2022 - 08/2002
33Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
02/2022 - 07/2007
29Neurodegenerative Diseases (Neurodegenerative Disease)
01/2022 - 06/2004
29Motor Neuron Disease (Primary Lateral Sclerosis)
01/2022 - 03/2003
16Parkinson Disease (Parkinson's Disease)
06/2022 - 08/2006
16Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar)
04/2021 - 03/2012
15Disease Progression
06/2022 - 06/2006
14Muscle Weakness
08/2022 - 06/2006
14Atrophy
07/2022 - 11/2009
12Demyelinating Diseases (Demyelinating Disease)
02/2021 - 11/2010
11Alzheimer Disease (Alzheimer's Disease)
05/2022 - 08/2006
11Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)
11/2021 - 06/2011
9Amyloidosis
12/2021 - 12/2009
9Muscular Atrophy (Muscle Atrophy)
01/2020 - 08/2006
9Neuromuscular Diseases (Neuromuscular Disease)
01/2020 - 01/2015
8Pain (Aches)
06/2022 - 01/2009
7Polyneuropathies (Polyneuropathy)
12/2021 - 01/2015
6Orthostatic Hypotension (Postural Hypotension)
05/2020 - 01/2016
6Huntington Disease (Huntington's Disease)
01/2020 - 06/2004
6Spinocerebellar Ataxias (Spinocerebellar Ataxia)
01/2020 - 06/2004
5Vasculitis (Vasculitides)
10/2022 - 11/2017
5Inclusion Body Myositis
01/2022 - 01/2017
5Deglutition Disorders (Dysphagia)
01/2022 - 06/2006
5Familial Amyloid Neuropathies (Familial Amyloid Polyneuropathy)
12/2018 - 12/2009
4Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
10/2022 - 01/2020
4Nervous System Heredodegenerative Disorders
07/2022 - 11/2006
4Churg-Strauss Syndrome (Allergic Angiitis)
07/2022 - 01/2020
4Inflammation (Inflammations)
03/2022 - 02/2005
4Transthyretin-Related Hereditary Amyloidosis
12/2020 - 11/2011
4Cognitive Dysfunction
05/2020 - 01/2016
4Frontotemporal Dementia (Semantic Dementia)
01/2020 - 08/2009
4Dysarthria (Spastic Dysarthria)
12/2019 - 06/2006
3Microscopic Polyangiitis
10/2022 - 11/2017
3Fatigue
06/2022 - 03/2018
3Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
05/2022 - 01/2020
3Muscular Diseases (Myopathy)
01/2022 - 11/2018
3Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy)
01/2022 - 11/2007
3Nervous System Diseases (Neurological Disorders)
01/2022 - 08/2018
3Multiple System Atrophy
01/2022 - 05/2020
3Immunoglobulin Light-chain Amyloidosis
11/2021 - 02/2021
3Paraproteinemias (Monoclonal Gammopathy)
11/2021 - 01/2015
3Myasthenia Gravis
01/2021 - 02/2016
3Sarcoma (Soft Tissue Sarcoma)
01/2020 - 01/2017
3Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy)
01/2020 - 05/2008
3Speech Disorders (Cluttering)
01/2020 - 10/2016
3Stroke (Strokes)
01/2020 - 01/2016
3Mitochondrial Diseases (Mitochondrial Disease)
12/2012 - 11/2009
2Tauopathies
05/2022 - 01/2022

Drug/Important Bio-Agent (IBA)

51Androgen Receptors (Androgen Receptor)IBA
07/2022 - 08/2002
47polyglutamineIBA
01/2022 - 08/2002
32Proteins (Proteins, Gene)FDA Link
07/2022 - 03/2003
20AntibodiesIBA
12/2021 - 02/2011
12AndrogensIBA
07/2022 - 04/2007
12Biomarkers (Surrogate Marker)IBA
01/2022 - 03/2012
11Amyloid (Amyloid Fibrils)IBA
05/2022 - 12/2009
11DNA-Binding Proteins (DNA Binding Protein)IBA
04/2021 - 08/2009
10Prealbumin (Transthyretin)IBA
12/2021 - 12/2009
8Monoclonal AntibodiesIBA
08/2021 - 01/2016
8AutoantibodiesIBA
08/2021 - 01/2017
7Intravenous Immunoglobulins (IVIG)FDA Link
11/2021 - 01/2009
7Messenger RNA (mRNA)IBA
08/2021 - 01/2012
7RNA (Ribonucleic Acid)IBA
01/2020 - 01/2013
7RNA-Binding Proteins (RNA-Binding Protein)IBA
01/2020 - 01/2013
6Testosterone (Sustanon)FDA Link
01/2022 - 08/2002
6Leuprolide (Lupron)FDA LinkGeneric
01/2022 - 06/2003
6Pharmaceutical PreparationsIBA
01/2022 - 11/2018
6CreatinineIBA
10/2021 - 09/2012
5Complement System Proteins (Complement)IBA
10/2022 - 11/2010
5Antineutrophil Cytoplasmic Antibodies (ANCA)IBA
10/2022 - 11/2017
5SteroidsIBA
01/2022 - 09/2019
5Myelin-Associated GlycoproteinIBA
11/2021 - 09/2010
5DNA (Deoxyribonucleic Acid)IBA
01/2021 - 01/2013
4Antisense OligonucleotidesIBA
12/2021 - 11/2015
4UbiquitinIBA
01/2021 - 12/2009
4Immunoglobulin M (IgM)IBA
12/2020 - 09/2010
4Insulin-Like Growth Factor I (IGF-1)IBA
12/2018 - 08/2009
3Acetates (Acetic Acid Esters)FDA Link
01/2022 - 12/2017
3Small Interfering RNA (siRNA)IBA
12/2021 - 02/2019
3Cholinergic ReceptorsIBA
11/2021 - 12/2019
3bimagrumabIBA
01/2021 - 01/2019
3Proteasome Endopeptidase Complex (Proteasome)IBA
01/2021 - 12/2009
3Sodium Channels (Sodium Channel)IBA
12/2020 - 11/2015
3hydroxide ionIBA
05/2020 - 01/2017
33-Iodobenzylguanidine (Iobenguane)IBA
12/2018 - 11/2017
3Biological ProductsIBA
01/2018 - 07/2013
3Protein Isoforms (Isoforms)IBA
01/2017 - 12/2012
3Mutant Proteins (Protein, Mutant)IBA
12/2009 - 08/2006
3tanespimycin (17AAG)IBA
11/2006 - 10/2005
2Monoamine Oxidase (MAO)IBA
06/2022 - 01/2018
2Volatile Fatty AcidsIBA
06/2022 - 12/2020
2MucinsIBA
06/2022 - 12/2020
2Abatacept (Orencia)FDA Link
03/2022 - 10/2019

Therapy/Procedure

35Therapeutics
10/2022 - 06/2006
6Molecular Targeted Therapy
07/2012 - 08/2006
4Denervation
01/2022 - 05/2013
4Deep Brain Stimulation
12/2021 - 10/2016
4Activities of Daily Living (ADL)
06/2019 - 06/2006
3Electrodes (Electrode)
08/2021 - 01/2016
3Liver Transplantation
12/2020 - 11/2011
2Immunotherapy
03/2022 - 11/2021